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The accuracy of results from DFT calculations can be poor to fairly good, and are taken from the "standard Cambridge" sequence) Rearrangements (large-scale partial deletions and duplications) Chronic progressive external ophthalmoplegia (CPEO) Kearn's Sayre syndrome Diabetes and deafness Pearson marrow-pancreas syndrome Sporadic tubulopathy Point mutations Protein-encoding genes LHON (G11778A, T14484C, G3460A) NARPLeigh syndrome (T8993GC) tRNA genes MELAS (A3243G, T3271C, A3251G) MERRF (A8344G, T8356C) CPEO (A3243G, T4274C) Myopathy (T14709C, Al 2320G) Cardiomyopathy (A3243G, A4269G, A4300G) Diabetes and deafness (A3243G, C12258A) Encephalomyopathy (G1606A, T10010C) rRNA genes Non-syndromic sensorineural deafness (A7445G) Aminoglycoside induced non-syndromic deafness (A1555G) Nuclear genetic disorders Disorders of mtDNA maintenance Autosomal dominant progressive external ophthalmoplegia (with 2° multiple mtDNA deletions) Mutations in adenine nucleotide translocator (ANT1) Mutations in DNA polymerase y (POLG) Mutations in Twinkle helicase (ClOorfl) Mitochondrial neuro-gastrointestinal encephalomyopathy (with 2° multiple mtDNA deletions) Mutations in thymidine phosphorylase (TP) Myopathy with mtDNA depletion Mutations in thymidine kinase (TK2) Encephalopathy with liver failure Mutations in deoxyguanosine kinase (DGK) Inheritance pattern S S S S S M M M M M M M M M M M Inheritance pattern AD AD or AR AD AR AR AR 282 Microfabrication and Nanomanufacturing Thus, σr 2Pcosθ'.
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